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Metahumans are in the world of DC comics, typically anyone with superpowers or unique abilities. Many heroes and villains in the DC universe possess metahuman qualities. The term first came about in a 1988 story titled “Invasion!,” where an alien race known as the Dominators coined the phrase.
The new Flash television show will profile several metahumans besides the title character. The confirmed metahuman characters in the show will include Weather Wizard, Girder and Firestorm, and the Mist. It is unclear yet as to whether Captain Cold, Heatwave, and the Pied Piper—all of whom are confirmed for the show—will be depicted as metahuman characters or not.
Source: comicbook.com