The official description of the role states “Owain Yeoman plays longtime DC Comics villain Vartox, an alien convict, who has been hiding on Earth for the past twelve years. After Supergirl’s emergence on Earth, Vartox seeks her out to ascertain her identity and do battle with her.”
Vartox first appeared in 1974’s “Superman” #281, created by Cary Bates and Curt Swan.
The cast of Supergirl includes lead Melissa Benoist as Kara/Supergirl, Chyler Leigh as Alexandra “Alex” Danvers, Mehcad Brooks as James Olsen, Laura Benanti as Alura Zor-El, Calista Flockhart as Cat Grant, David Harewood as Hank Henshaw, and Jeremy Jordan as Winslow Schott.
Ali Adler (No Ordinary Family), Greg Berlanti (Arrow) and Andrew Kreisberg (The Flash and Arrow) are writers on the series. Glen Winter is directing the pilot episode from a script written by Ali Adler and Greg Berlanti, both are serving as executive producers alongside Sarah Schechter and Andrew Kreisberg.
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Source: Comic Book Resources